Dotarizine is a drug used in the treatment of migraine, which acts as a calcium channel blocker, and also as an antagonist at the 5HT<sub>2A</sub> receptor, and to a lesser extent at the 5HT<sub>1A</sub> and 5HT<sub>2C</sub> receptors. The anti-migraine action is thought to be due to its action as a vasodilator, but it also has some anxiolytic effects and blocks amnesia produced by electroconvulsive shock in animals.