In enzymology, a diethyl 2-methyl-3-oxosuccinate reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are diethyl (2R,3R)-2-methyl-3-hydroxysuccinate and NADP<sup>+</sup>, whereas its 3 products are diethyl 2-methyl-3-oxosuccinate, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is diethyl-(2R,3R)-2-methyl-3-hydroxysuccinate:NADP<sup>+</sup> 3-oxidoreductase.