Dichloropane ((âÂÂ)-2ò-Carbomethoxy-3ò-(3,4-dichlorophenyl)tropane, RTI-111, O-401) is a stimulant of the phenyltropane class that acts as a serotoninâÂÂnorepinephrineâÂÂdopamine reuptake inhibitor (SNDRI) with IC<sub>50</sub> values of 3.13, 18, and 0.79 nM, respectively. In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine.
Methylecgonidine is the direct precursor to this compound.
The thermodynamic isomer with a trans -CO<sub>2</sub>Me group is still active. This isomer was used by Neurosearch to make three different phenyltropanes which were tested in clinical trials.