de Soto is a Spanish surname. Notable people with the surname include:
- Alexander de Soto (1840âÂÂ1936), Spanish-American physician, businessman, and philanthropist
- ÃÂlvaro de Soto (born 1943), Peruvian diplomat and UN envoy
- Benito de Soto (1805âÂÂ1830), pirate
- Domingo de Soto (1494âÂÂ1560), Spanish theologian
- Ernest de Soto (1923âÂÂ2014), American printmaker and lithographer
- Ernestine Ygnacio-De Soto, Barbareño Chumash activist and historian
- Francisco de Soto (), Spanish organist and composer
- Hernando de Soto (), Spanish conquistador
- Hernando de Soto Polar (born 1941), Peruvian economist and author
- Jesús Huerta de Soto (born 1956), economist, born in Spain
- Luis Barahona de Soto (1548âÂÂ1595), Spanish poet
- Pedro de Soto (1493âÂÂ1563), Spanish theologian