In enzymology, a corydaline synthase () is an enzyme that catalyzes the chemical reaction
The 4 substrates of this enzyme are S-adenosyl methionine, palmatine, NADPH, and H<sup>+</sup>, whereas its 3 products are S-adenosylhomocysteine, corydaline, and NADP<sup>+</sup>.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.