Copper(II) trifluoroacetate is the trifluoroacetate of divalent copper with the chemical formula .
It exists as the anhydride, hydrate and adducts of other solvents. The hydrate begins to lose two waters of crystallisation at , and loses all crystal water at to form the anhydrous form. This begins to decompose at .
Copper trifluoroacetate can be obtained by reacting trifluoroacetic acid with copper oxide, copper hydroxide or basic copper carbonate. Acetone can replace the water molecules in copper trifluoroacetate hydrate, and under reduced pressure conditions, the acetone can be removed to obtain anhydrous material.
Copper trifluoroacetate finds some use as a reagent in organic chemistry. For example, it mediates the bond arylation of arenes with arylboronic acids and is used in the arylation of indoles with triphenylbismuth bis-trifluoroacetate. It is also a catalyst for the aerobic oxidation of ethers.
Copper trifluoroacetate forms adducts with a variety of Lewis bases, such as ammonia, water, dioxane, and quinoline. The Lewis bases bind to the axial positions.