Clorgiline (), or clorgyline (), is a monoamine oxidase inhibitor (MAOI) and investigational antidepressant related to pargyline. Specifically, it is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A). Clorgiline was never marketed, but it has found use in scientific research.
In addition to its MAOI activity, it has been found to bind with high affinity to the ÃÂ<sub>1</sub> receptor (K<sub>i</sub> = 3.2âÂÂ510nM) and with very high affinity to the imidazoline I<sub>2</sub> receptor (K<sub>i</sub> = 40pM). Unlike selegiline, clorgiline does not appear to be a monoaminergic activity enhancer (MAE).
Clorgiline is also a multidrug efflux pump inhibitor. Holmes et al., 2012 reverse azole fungicide resistance using clorgiline, showing promise for its use in multiple fungicide resistance.