In enzymology, a chlordecone reductase () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are chlordecone alcohol and NADP<sup>+</sup>, whereas its 3 products are chlordecone, NADPH, and H<sup>+</sup>.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is chlordecone-alcohol:NADP<sup>+</sup> 2-oxidoreductase. This enzyme is also called CDR.
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .