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Carbamoyl-serine ammonia-lyase

The enzyme carbamoyl-serine ammonia-lyase (EC 4.3.1.13) catalyzes the chemical reaction

O-carbamoyl-<small>L</small>-serine + H<sub>2</sub>O = pyruvate + 2 NH<sub>3</sub> + CO<sub>2</sub> (overall reaction)
:(1a) O-carbamoyl-<small>L</small>-serine = CO<sub>2</sub> + NH<sub>3</sub> + 2-aminoprop-2-enoate
:(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous)
:(1c) 2-iminopropanoate + H<sub>2</sub>O = pyruvate + NH<sub>3</sub> (spontaneous)

This enzyme belongs to the family of lyases, specifically ammonia lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is O-carbamoyl-<small>L</small>-serine ammonia-lyase (decarboxylating; pyruvate-forming). Other names in common use include O-carbamoyl-<small>L</small>-serine deaminase, carbamoylserine deaminase, and O-carbamoyl-<small>L</small>-serine ammonia-lyase (pyruvate-forming). It employs one cofactor, pyridoxal phosphate.

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