Arachidonyl-2'-chloroethylamide (ACEA) is a synthetic agonist of the CB<sub>1</sub> (CB1R). ACEA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the CB<sub>2</sub> (CB2R) (K<sub>i</sub> = 1.4 nM for CB1R; K<sub>i</sub> = 3100 nM for CB2R).