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Androstenetriol

Androstenetriol (AET, androst-5-ene-3β,7β,17β-triol, β-androstenetriol, or β-AET) is a steroid produced in the adrenal glands as a metabolite of dehydroepiandrosterone (DHEA). It is believed to have similar effects as DHEA and androstenediol. A study in rodents found that the compound was a weak androgen and estrogen, but did not bind to the androgen, estrogen, progesterone, or glucocorticoid receptors. Synthetic analogues of androstenetriol such as bezisterim (HE3286, NE3107; the 17α-ethynylated derivative) have been developed and are under study.

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