Androstanedione, also known as 5ñ-androstanedione or as 5ñ-androstane-3,17-dione, is a naturally occurring androstane (5ñ-androstane) steroid and an endogenous metabolite of androgens like testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), and androstenedione. It is the C5 epimer of etiocholanedione (5ò-androstanedione). Androstanedione is formed from androstenedione by 5ñ-reductase and from DHT by 17ò-hydroxysteroid dehydrogenase. It has some androgenic activity.
In female genital skin, the conversion of androstenedione into DHT through 5ñ-androstanedione appears to be more important than the direct conversion of testosterone into DHT.