3ñ-Androstanediol glucuronide (3ñ-ADG) is a metabolite formed from human androgens; compounds involved in the development and maintenance of sexual characteristics. It is formed by the glucuronidation of dihydrotestosterone, and has been proposed as means of measuring androgenic activity.
In women the adrenal steroids, dehydroepiandrosterone sulfate, androstenedione and dehydroepiandrosterone are the major precursors of plasma 3ñ-ADG, accounting for almost the totality of circulating 3ñ-ADG. Levels of 3ñ-ADG decrease significantly with age.
3ñ-ADG is used as a marker of target tissue cellular action. 3ñ-ADG correlates with level of 5ñ-reductase activity (testosterone and 3ñ-androstanediol to dihydrotestosterone) in the skin. Concentrations of 3ñ-ADG are associated with the level of cutaneous androgen metabolism.