The enzyme ñ-<small>L</small>-fucosidase () catalyzes the following chemical reaction: an ñ-<small>L</small>-fucoside + H<sub>2</sub>O <small>L</small>-fucose + an alcohol
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is ñ-<small>L</small>-fucoside fucohydrolase. This enzyme is also called ñ-fucosidase. It participates in N-glycan degradation and glycan structure degradation.
Deficiency of this enzyme is called fucosidosis.
In CAZy, ñ-<small>L</small>-fucosidases are found in glycoside hydrolase family 29 and glycoside hydrolase family 95.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .
It was in a recent study by Endreffy, Bjørklund and collaborators (2017) found an association between the activity of ñ-<small>L</small>-fucosidase-1 (FUCA-1) and chronic autoimmune disorders in children. This should encourage further research on FUCA-1 as a marker of chronic inflammation and autoimmunity. Recently, there have been focus on various engineering strategies to make fucosynthase to fucosidase.