Acquired hemolytic anemia

Acquired hemolytic anemia can be divided into immune and non-immune mediated forms of hemolytic anemia.

Classification

Immune

• Autoimmune hemolytic anemia
• Warm antibody autoimmune hemolytic anemia
• Idiopathic
• Linked with primary immunodeficiency/immunodysregulation syndrome.
• Lymphoma or chronic lymphocytic leukemia associated.
• Secondary to other malignancies.
• Associated with SLE or other collagen-vascular disorders.
• Secondary to viral infection.
• Cold antibody autoimmune hemolytic anemia
• Paroxysmal cold hemoglobinuria
• Drug-induced autoimmune hemolytic anemia
• Alloimmune hemolytic anemia
• Hemolytic disease of the newborn (HDN)
• Rh disease (Rh D)
• ABO hemolytic disease of the newborn
• Anti-Kell hemolytic disease of the newborn
• Rhesus c hemolytic disease of the newborn
• Rhesus E hemolytic disease of the newborn
• Other blood group incompatibility (RhC, Rhe, Kidd, Duffy, MN, P and others)
• Alloimmune hemolytic blood transfusion reactions (i.e., from a non-compatible blood type)

Non-immune

• Traumatic hemolytic anemia
• Impact
• Macrovascular defects-prostheses
• Microvascular causes
• Disseminated intravascular hemolysis
• Thrombotic thrombocytopenic purpura
• Typical and atypical hemolytic uremic syndrome
• Other microvascular abnormalities
• Hypersplenism
• Hemolytic anemia due to toxic effects on the membrane
• Spur cell anemia
• External toxins
• Animal or spider bites
• Metals
• Organic compounds
• Infectious agents
• Paroxysmal nocturnal hemoglobinuria (PNH)

History

The term 'acquired hemolytic anemia' originally appeared in the early 1900s.

References

Further reading

External links