Zuojhen District () is a rural district of about 4,410 residents in Tainan, Taiwan.
After the handover of Taiwan from Japan to the Republic of China in 1945, Zuojhen was organized as a rural township of Tainan County. On 25 December 2010, Tainan County was merged with Tainan City and Zuojhen was upgraded to a district of the city.
The district consists of Guanghe, Ronghe, Zuozhen, Zhongzheng, Muguang, Neizhuang, Dengshan, Ganglin, Caoshan and Erliao Village.