Zakhele Sipho Mkhize (born 6 September 1950) is a South African politician who represented the KwaZulu-Natal constituency in the National Assembly from 2004 to 2009. A member of the African National Congress, he was elected in the 2004 general election, ranked eighth on the party's regional list for KwaZulu-Natal. He did not stand for re-election in 2009.