Zinc finger FYVE domain-containing protein 9 or SARA (<u>S</u>MAD <u>a</u>nchor for <u>r</u>eceptor <u>a</u>ctivation) is a protein that in humans is encoded by the ZFYVE9 gene. SARA contains a double zinc finger (FYVE domain).
SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates from SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors.