Yuzhnoye Medvedkovo District () is a territorial division (a district, or raion) in North-Eastern Administrative Okrug, one of the 125 in the federal city of Moscow, Russia. It is located in the north of the federal city. The area of the district is . As of the 2010 Census, the total population of the district was 81,986.
As a municipal division, the district is incorporated as Yuzhnoye Medvedkovo Municipal Okrug.