York Run is a long 3rd order tributary to Georges Creek in Fayette County, Pennsylvania.
According to the Geographic Names Information System, it has also been known historically as:
York Run rises about 0.75 miles (1,2 km) southwest of Chadville, Pennsylvania, and then flows southwest to join Georges Creek about 2.5 miles (4.0 km) southwest of Smithfield.
York Run drains of area, receives about 43.3 in/year (1100 mm/a) of precipitation, has a wetness index of 373.76, and is about 48% forested.