Yi Prefecture, Yi Zhou, or Yizhou may refer to:
- Yizhou (Southwest China) (), a historical province of China covering southwest China
- Yi Prefecture (Shandong) (), active between the 7th and 18th centuries
- Yi Prefecture (Guangxi) (), active between the 7th and 13th centuries
- Yi Prefecture (Hebei) ()
- Yi Prefecture (Korea), now known as Uiju or Uiju County
- Yizhou District, Hechi (), district of Hechi, Guangxi named after the historical prefecture
- Yizhou District, Hami (), district of Hami, Xinjiang
- Yizhou (island) (), a legendary island in ancient Chinese texts, possibly referencing Taiwan or the Ryukyus
See also