Yeso is an unincorporated community in De Baca County, New Mexico, United States, located along U.S. Route 60 west of Fort Sumner.
The community took its name from nearby Yeso Creek. The post office has been in operation at Yeso since 1909.
Yeso was laid out in 1906 when the railroad was extended to that point. However, as the steam engine fell into decline, so did the community. Coupled with unsanitary drinking water, and closure of the school, the decline of the community led to its eventual abandoning in 1966, making it a ghost town.