Xanthesma isae, or Xanthesma (Chaetohesma) isae, is a species of bee in the family Colletidae and the subfamily Euryglossinae. It is endemic to Australia. It was described in 1978 by Australian entomologist Elizabeth Exley.
The species occurs in north-west Queensland. The type locality is 20 km north of Mount Isa.
The adults are flying mellivores. Flowering plants visited by the bees include Eucalyptus species.