The X-factor in astrophysics, often labeled X<sub>CO</sub>, is an empirically determined proportionality constant which converts carbon monoxide (CO) emission line brightness to molecular hydrogen (H<sub>2</sub>) mass. The term X-factor was coined in a 1983 paper titled "Gamma-rays from atomic and molecular gas in the first galactic quadrant" and published in The Astrophysical Journal.
Calibrating X<sub>CO</sub> requires an independent method of determining the amount of molecular hydrogen in a given astrophysical region. While direct emission from molecular hydrogen is difficult to observe, there are other ways of inferring molecular hydrogen mass, outlined below.