Wythenshawe was an electoral division of Manchester City Council which was represented from 1931 until 1954. It covered the Wythenshawe estate to the south the city.
Wythenshawe ward was created in 1931, following the Manchester Extension Act 1930, which gave the civil parishes of Baguley, Northenden, and Northen Etchells to the Manchester corporation. It covered the former civil parishes, previously part of the Bucklow Rural District, which became the Wythenshawe estate. Its boundaries were altered in 1950, with that part of the ward north of the Cheshire Lines Railway transferred to the new Northenden ward. In 1954, the ward was abolished, and its former area was divided between the Baguley, Benchill, and Woodhouse Park wards.
From 1931 until 1945, the ward formed part of the Altrincham Parliamentary constituency. From 1945 until 1950 it was part of the Bucklow Parliamentary constituency. From 1950 until its abolition it was part of the Manchester Wythenshawe Parliamentary constituency.