The Wyoming Republican Party is the affiliate of the Republican Party in Wyoming. It is currently the dominant party in the state, and is one of the strongest affiliates of the national Republican Party. The party currently controls Wyoming's at-large U.S. House seat, both U.S. Senate seats, the governorship, and has nearly unanimous positions in both houses of the state legislature.
In 2021, the Wyoming Republican Party voted to stop recognizing Liz Cheney as a Republican. Cheney had criticized former president Donald Trump for attempting to overturn the 2020 election results after he lost the election and inciting a pro-Trump mob to assault the U.S. Capitol. In 2022, the Wyoming Republican Party supported a primary challenger against Cheney.