Wyoming Highway 254 (WYO 254) is a state road northwest of Casper, Wyoming known as Salt Creek Highway.
Wyoming Highway 254 begins its south end the town of Mills, just outside Casper at US 20 Business/US 26 Business (Yellowstone Highway). The highway continues north into the town of Bar Nunn at 0.79 miles (located northwest of Casper). Highway 254 intersects US 20/US 26 (Casper Bypass) at . WYO 254 continues north until , where it turns east onto Wardwell Road for a short distance and there meets I-25/US 87 (exit 191), where WYO 254 ends.
Wyoming Highway 254 is the former alignment of US 87 prior to relocation along I-25.