Wyoming Highway 253 (WYO 253), Hat Six Road, is a state highway in eastern Natrona County, Wyoming, United States, that connects Natrona County Road 606 (CR 606), southeast of Casper, with U.S. Route 20 / U.S. Route 26 / U.S. Route 87 (US 20 / US 26 / US 87) and Wyoming Highway 256 (WYO 256) in Evansville.
WYO 253 begins at the north end of CR 606 (Hat Six Road), near the Natrona-Converse county line and southeast of Casper. From its southern terminus heads northerly and promptly connects with the north end of Natrona County Road 607 (Smith Creek Road). From there, WYO 253 travels generally northwest. As it enters Evansville, WYO 253 has a diamond interchange with Interstate 25 (Exit 182) at and shortly thereafter reaches its northern terminus at an intersection with US 20 / US 26 / US 87 (East Yellowstone Highway / Old Glenrock Highway) and the southern terminus of WYO 256 (Cole Creek Road). The mileposts for Highway 253 increase from north to south.