Wyoming Highway 160 (WYO 160) is a short east–west Wyoming State Road located in western Goshen County in the town of Fort Laramie.
Wyoming Highway 160 is a short route at only in length that provides access to the Fort Laramie National Historic Site and areas west and southwest of Fort Laramie. Highway 160 begins at Goshen CR 53 and travels east, passing north of the Fort Laramie Historic Site. WYO 160 crosses the North Platte River before reaching Fort Laramie where the highway ends at US Route 26 (Merriam Street).
Wyoming Highway 160 may have previously been routed all the way to Interstate 25 (Exit 80) in Wheatland. WYO 160 would have traveled south of Grayrocks Reservoir to Wheatland. The roadway today appears to be a county-maintained road.