Wyethia arizonica, the Arizona mule's ears, is a plant species native to Arizona, Colorado, New Mexico and Utah. It grows in meadows in coniferous forests at elevations of .
Wyethia arizonica is a perennial herb with a large taproot, the shoot up to tall. Leaves are elliptic to lanceolate, up to long. Flower heads are 1-4 per plant, with yellow flowers.