Wyeth is an unincorporated community in Andrew County, Missouri, United States.
The community is on Route C approximately southeast of Rosendale. The One Hundred and Two River flows past about to the west.
An old variant name was Rush, after Peter Rush, a local landowner. A post office called Rush was established in 1890, the name was changed into Wyeth in 1904, and the post office closed in 1905.