Wortham is a census-designated place in St. Francois County, in the U.S. state of Missouri.
As of the 2020 census, Wortham had a population of 197.
Wortham was originally called "Cherrytown", and under the latter name was platted in 1904. A post office called Wortham was established in 1925 and remained in operation until 1969. An early postmaster, Ray Wortham, gave the community its name.