Worknesh Degefa (; born October 28, 1990) is an Ethiopian long-distance road runner. , she is the fourth-fastest female marathoner in history, based on her 2:17:41 run at the Dubai Marathon, January 25, 2019. The winner of the race in Dubai was Ruth Chepngetich, who holds the third-best marathon time. Degefa had won Dubai in 2017 in 2:22:36. She returned in 2018 to run 2:19:53, finishing fourth behind three other Ethiopians, all of whom achieved rankings in the top 25 of all time. It was the first time four women had run under 2:20 in the same race. , she is also ranked just outside the top 25 in the half marathon, running 1:06:14 at the Prague Half Marathon in 2016.
On April 15, 2019, Degefa won the Boston Marathon in 2:23:31 in front-running fashion, by surging away from the field only 8 km into the race, despite never having seen the course before, even in training. By the 30 km mark, she had opened up an almost 3 minute lead over the chasers. Edna Kiplagat ran down Heartbreak Hill in an effort to catch Degefa, narrowing the gap to 42 seconds by the finish.