Wolf Creek is a stream in eastern St. Francois County in the U.S. state of Missouri. It is a tributary of the St. Francis River.
The stream headwaters arise just northeast of Farmington at at the confluence of Camp Creek and Taylor Branch. The stream flows south passing under Missouri Route 32. It flows southwest to its confluence with the St. Francis at at an elevation of .
Wolf Creek was so named due to the presence of wolves in the area.