Wisacky is an unincorporated community and census-designated place (CDP) in Lee County, South Carolina, United States. It was first listed as a CDP prior to the 2020 census with a population of 185.
The CDP is in eastern Lee County, centered on the junction of South Carolina Highways 341 and 527. Highway 341 leads northwest to Bishopville, the county seat, and southeast to Lynchburg, while Highway 527 leads south-southeast to Kingstree.