Frederik Willem Wepener (born 2 April 1981) is a South African rugby union footballer. He plays as a hooker for the in Super Rugby and the in the Currie Cup. Wepener has previously represented Clermont Auvergne, Griquas, the Leopards and the .
In August 2013, he rejoined the for the third time, signing a two-year contract with the Johannesburg-based team.