William Preston may refer to:
- William Preston (actor) (1921âÂÂ1998)
- William Preston (Freemason) (1742âÂÂ1818), Scottish author of Illustrations of Masonry
- William Preston (Kentucky soldier) (1816âÂÂ1887), U.S. politician, ambassador, and Confederate officer
- William Preston (poet) (1753âÂÂ1807), Irish poet
- William Preston (Virginia soldier) (1729âÂÂ1783), Irish-born frontier Virginia leader, signer of the Fincastle Resolutions
- William Preston (Royal Navy officer), captain in the British Royal Navy who, along with James Stirling, was responsible for the foundations of Perth and Fremantle in Western Australia
- William Preston (British politician) (1874âÂÂ1941), Conservative M.P. for Walsall, 1924âÂÂ1929
- William Alfred Preston (1848âÂÂ1944), MPP in Ontario, Canada
- William B. Preston (Mormon) (1830âÂÂ1908), Presiding Bishop of the Church of Jesus Christ of Latter-day Saints, 1884âÂÂ1907
- William B. Preston (1805âÂÂ1862), U.S. politician from Virginia
- William C. Preston (1794âÂÂ1860), U.S. politician from Pennsylvania who was a U.S. senator for South Carolina
- William G. Preston (1842âÂÂ1910), American architect
- William Preston (bishop) (1729âÂÂ1789), Anglican bishop in Ireland
- Billy Preston (1946âÂÂ2006), American musician
- Billy Preston (basketball) (born 1997), American basketball player
- Bill Preston (1893âÂÂ1954), American football tackle
Fictional
- Sergeant William Preston of the Northwest Mounted Police, lead character in the radio and TV series Challenge of the Yukon