The William F. and Julia Crome House is a historic house located at 305 South Second Street in Clinton, Henry County, Missouri.
It was built in 1904, and is two-story, American Foursquare style brick dwelling with Colonial Revival style design elements. It has an intersecting hip roof with five dormers and a full-width front porch. Also on the property is a contributing brick garage.
It was listed on the National Register of Historic Places on March 25, 1999.