William Chisholm Macdonald (6 May 1890 – 19 November 1946) was a Liberal party member of the House of Commons of Canada. He was born in Bailey's Brook, Nova Scotia and became a barrister by career.
He was first elected to Parliament at the Halifax riding in the 1940 general election and re-elected in 1945. Macdonald died on 19 November 1946 before completing his term in the 20th Canadian Parliament.