Wilkesboro-Smithey Hotel, also known as the Smithey Hotel or Smithey's Department Store, is a historic hotel building located at Wilkesboro, Wilkes County, North Carolina. It was built in 1891, and is a three-story, nine bay by six bay, brick building. It features a two-story wraparound gallery porch.
It was listed on the National Register of Historic Places in 1982.