Whitethorn Creek is a long 4th order tributary to the Banister River in Pittsylvania County, Virginia. The Whitehorn Creek watershed and its tributary, Mill Creek, are the location of one of the largest uranium deposits in the United States on Cole Hill.
According to the Geographic Names Information System, it has also been known historically as:
Whitethorn Creek rises about 0.5 miles south-southeast of Pickerel, Virginia and then flows southeast to join the Banister River at Markham.
Whitethorn Creek drains of area, receives about 45.5 in/year of precipitation, has a wetness index of 432.34, and is about 46% forested.