The Whitesand River is a river in Thunder Bay District, Ontario, Canada, that flows south into the northwest side of Lake Nipigon.
The river begins at Selassie Lake at an elevation of . Selassie Lake is adjacent to Haile Lake, which also flows into Lake Nipigon, but via the Pikitigushi River system. The names of the two lakes are a reference to Haile Selassie I of Ethiopia.
From Selassie Lake, the river flows southwest and then south to where the right tributary Blackett Creek joins at an elevation of . It continues south and enters Whitesand Lake at an elevation of . The river then continues further south for a total distance from Selassie Lake of to JoJo Lake at an elevation of . Here the Canadian National Railway transcontinental line crosses the river at the south end of the lake at a point just east of Armstrong Airport and about east of the community of Armstrong, Thunder Bay District, Ontario.
The river then travels further south to a waterfall, and then another southeast to its mouth at Lake Nipigon, for a total distance from Selassie Lake of .