Whetstone Creek is a north flowing stream in Wright County, Missouri, United States, that is a tributary of the Gasconade River.
The stream's headwaters are just south of Mountain Grove and cross under U. S. Route 60 just west of that city. The stream meanders north crossing under Route N and continuing roughly parallel with Route E past Owens and under Missouri Route 38 east of Rayborn to its confluence with the Gasconade River.
Whetstone Creek was named for the fact whetstones were sourced from its banks.