Weyanoke is an unincorporated community in West Feliciana Parish, Louisiana, United States. Weyanoke is located on Louisiana Highway 66, north-northwest of St. Francisville. Weyanoke has a post office with ZIP code 70787. Some sites that are listed on the National Register of Historic Places within Weyanoke are St. Mary's Episcopal Church , Rosebank Plantation House and the Weyanoke house.