West Brule is an unincorporated community and census-designated place (CDP) within the Lower Brule Indian Reservation in Lyman County, South Dakota, United States. It was first listed as a CDP prior to the 2020 census. The population of the CDP was 538 at the 2020 census.
It is in the northeast part of the county, west of Lower Brule and south of Lake Sharpe on the Missouri River.