Wellsboro Historic District, is a national historic district in Wellsboro, Tioga County, Pennsylvania, United States. It includes 531 contributing buildings, three contributing sites, and four contributing objects. It is a district that is a mixed use commercial / residential / institutional district. The historic structures date from 1835 to the 1950s and include the Tioga County Court House (1835), Arcadia Theater (1924), First Presbyterian Church (1894), Green Free Library, Penn-Wells Hotel (c. 1910), First Presbyterian Church (1894), St. Paul's Episcopal Church (1899), United Methodist Church of Wellsboro (1905), and Wellsboro Diner (1939). Three previously listed properties are also included: the Robinson House, Jesse Robinson House, and Wellsboro Armory.
It was listed on the National Register of Historic Places in 2005.