Weedon Lois (or Lois Weedon) is a village and former civil parish, now in the parish of Weston and Weedon, in West Northamptonshire, England. It is about west of Towcester. In 1931 the parish had a population of 296.
The villages name means 'Heathen temple hill'. There is a well in the parish, named after St. Loys or Lewis, whose waters apparently cured the Blind and Leprous.
Before Christianity came there may have been an Anglo-Saxon pagan temple here.
The oldest parts of the Church of England parish church of SS Mary and Peter date from about 1100. It is a Grade II* listed building. Michael Aris is buried in the churchyard, while the authors Edith Sitwell, her brother Sacheverell Sitwell, and American novelist James Purdy are buried in the churchyard extension.
On 1 April 1935 the parish was abolished and merged with Plumpton to form "Weston & Weedon".