2ò-Propanoyl-3ò-(2-naphthyl)-tropane or WF-23 (Wake Forest-23, named after the university where it was first created) is a cocaine analogue. It is several hundred times more potent than cocaine at being a serotonin-norepinephrine-dopamine reuptake inhibitor.
As can be seen on PubMed, these acyl substituted phenyltropanes are highly potent MAT inhibitors and also have a very long half-life, spanning perhaps at least a few days; as the half-life of the dopamine transporter in rats was found to be 2âÂÂ3 days under normal conditions (with agonists, antagonists, and transporter inhibitors altering the half-life), it may be that WF-23 largely or mostly binds to its transporters until they are degraded.
WF-23 is made from methyl-ferruginine i.e. PC10080982 [152668-77-4].