WAY-166818 is a synthetic, nonsteroidal estrogen related to WAY-200070 which is used in scientific research. It acts as a highly selective full agonist of the ERò, with 57- and 164-fold selectivity for the ERò over the ERñ in the rat and mouse, respectively. At the human ERò and ERñ, WAY-166818 has IC<sub>50</sub> values of 29 nM and 1227 nM (25-fold difference), respectively. The compound has been verified to cross the blood-brain-barrier in rodents.