Virgin and Child with Two Angels may refer to one of these paintings:
- Virgin and Child with Two Angels (), by Sandro Botticelli, in Naples
- Virgin and Child with Two Angels (1468 or 1469), by Sandro Botticelli, in Strasbourg
- Virgin and Child with Two Angels (), by Cimabue, in National Gallery, UK
- Virgin and Child with Two Angels (), by Andrea del Verrocchio, in National Gallery, UK
- Madonna and Child (), by Filippo Lippi, in Uffizi Gallery, Italy
- Madonna and Child Enthroned with Two Angels (), by Gentile da Fabriano
- Madonna and Child with Two Angels, Saint Rose and Saint Catherine (), by Pietro Perugino, in Uffizi Gallery, Italy
- Madonna and Child with Two Musician Angels (1515 or 1516), by Correggio, in the Louvre